Basic Info.
Customized
Non-Customized
Certification
GMP, Hse, ISO 9001, USP, Bp
Specification
Pharmaceutical Grade
Product Description
Hot Sale Pharmaceutical Vitamin A 99% Pure Powder Isotretinoin CAS 4759-48-2
Quick View:Name | Isotretinoin |
Systematic (IUPAC) name | Isotretinoin; Raw Powder Isotretinoin; Material Isotretinoin ; Acne Isotretinoin; Isotretinoin Powder |
CAS number | 4759-48-2 |
Formula | C20H27O2 |
MW | 299.4277 |
Purity | 99.98% Isotretinoin |
Appearance | Isotretinoin characteristic powder |
Application | Isotretinoin is used to treat severe recalcitrant nodular acne (a certain type of severe acne) that has not been helped by other treatments, such as antibiotics. Isotretinoin is in a class of medications called retinoids. It works by slowing the production of certain natural substances that can cause acne. Isotretinoin has been used to treat certain other skin conditions and some types of cancer. |
Stock | bulk in stock |
Shelf life | 2 Years |
Storage | Isotretinoin should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. |
Isotretinoin Uses:
Vitamin A class drugs. It can rapidly and strongly inhibit the cell proliferation and differentiation process of skin glands cells. It has a high effect on severe nodular cystic acne. This product has a high gastrointestinal absorption, but invalid for topical administration. It is used for treating severe acnes which cannot be treated by other drugs. It also has some effects on treating cystic acne, the party of acne, rosacea, ichthyosis, follicular keratosis and pityriasis red hair and other skin diseases.
Isotretinoin belongs to the first generation of vitamin A acid. It is a stereoisomer of all-trans vitamin A acid. Oral administration has an anti-oil effect which has special effect on severe acne. The mechanism is as follows:
(1) it can reduce sebaceous gland and inhibit the activity of sebaceous gland, reducing the effect of secretion of the sebaceous glands, thus inhibiting the growth of Propionibacterium which relies on lipid environment.
(2) it has an anti-keratosis effect, can inhibit the excess proliferation of epidermal and promote its differentiation. It also reduces the keratosis of hair follicles and the catheter of sebaceous glands.
(3) it can also affect the function of lymphocytes and monocytes, and inhibit the chemotaxis of neutrophil, and thus having anti-inflammatory activity.
(4) it can exert its therapeutic effect by selectively binding Vitamin A acid nuclear receptors. It can inhibit the proliferation of acne rod bacilli. Moreover it has effects of immunity stimulation at low doses, but has immunity suppression effect at high doses.
(5) It can inhibit the biogenesis of collagenase and gelatinase in the skin, and can also inhibit the activity of ornithine decarboxylase. Owing to the major role of ornithine decarboxylase in inducing skin mutations, so isotretinoin can also suppress tumorigenesis.
(6) when subjects to topical administration, it has a similar mechanism of action as vitamin A acid which induces the proliferation of epidermal cell, promotes the differentiation of epidermal cell granular layer into the stratum corneum. It can also regulate the horny plug occurring during some abnormal cornification processes of Hair follicle sebaceous epithelium, and thus playing a therapeutic role.
COA: Product name | Isotretinoin (13-cis Vitamin A acid) |
CAS No. | 4759-48-2 | Packing | 100G/25KG |
Date of manufacturing | 2th, July, 2017 | Shelf life | 1th, July, 2019 |
Standard | USP34 |
ITEMS | SPECIFICATION | RESULTS |
Appearance | Yellow or orange crystalline powder | Complies |
Identification | Complies | Complies |
Loss on drying | Not more than 0.5% | 0.05% |
Residue on ignition | Not more than 0.1% | 0.02% |
Heavy metals | Not more than 0.002% | <0.002 |
Tretinoin | Not more than 1.0% | 0.1% |
Assay | 98%~102.0% | 99.8% |
Conclusion | Qualified |
Related Products:
Product Name | CAS No. | Purity |
Tetracaine | 94-24-6 | 99% |
Tetracaine HCl | 136-47-0 | 99% |
Benzocaine | 94-09-7 | 99% |
Benzocaine HCl | 23239-88-5 | 99% |
Lidocaine | 137-58-6 | 99% |
Lidocaine HCl | 73-78-9 | 99% |
Procaine | 59-46-1 | 99% |
Procaine HCl | 51-05-8 | 99% |
Prilocaine | 721-50-6 | 99% |
Prilocaine HCl | 1786-81-8 | 99% |
Levobupivacaine HCl | 27262-48-2 | 99% |
Ropivacaine HCl | 132112-35-7 | 99% |
Ropivacaine mesylate | 854056-07-8 | 99% |
Articaine hydrochloride | 23964-57-0 | 99% |
Dyclonine HCl | 536-43-6 | 99% |
Mepivacaine | 22801-44-1 | 99% |
Mepivacaine HCl | 1722-62-9 | 99% |
Chloroprocaine HCl | 3858-89-7 | 99% |
Etidocaine | 36637-18-0 | 99% |
Address:
No. 26, Zhurong Road, Hengyang, Hunan, China
Business Type:
Manufacturer/Factory
Business Range:
Chemicals
Management System Certification:
ISO 9001, ISO 20000, QC 080000
Company Introduction:
Hengyang Desen Biotechnology Co., Ltd. is a leading Chinese chemical Supplier. Our company integrates R&D, producing, operating and marketing into an organic whole. We have authority of export and import, and have experience of export for 14 years.
All the products are produced in Aseptic Laboratory under GMP conditions. Top quality is guaranteed. Your products will be tested again and again before it is package, then ship to your hand. If by some reasons you are not satisfied or you have any concerns, our hassle-free money back policy allows you to contact us within 30 days of package arrival.
We warmly welcome clients from all over the world to come to our factory for visit and cooperation!